2+ hour, 57+ min ago   (594+ words) Scientists discovered that aging cells can use malfunctioning mitochondria to unlock inflammatory genes and keep the immune system stuck in a prolonged state of alert. Blocking one part of this process reduced inflammation and improved healthy aging in mice, suggesting…...

16+ hour, 5+ min ago   (1023+ words) Researchers reconstructed ancient versions of a bacteria-killing protein found in tears and breast milk, and some were more powerful than the human version. Tears, saliva and breast milk all carry a protein that holds iron away from bacteria, which need…...

1+ day, 6+ min ago   (776+ words) Some worn-out cells don't quietly retire. They linger in tissues, release inflammatory signals and may make it harder for neighboring cells to function normally. Scientists call them senescent cells, and their accumulation with age has made them a major target…...

1+ day, 2+ hour ago   (73+ words) A single microRNA molecule may help determine whether the parasitic blood fluke Schistosoma japonicum thrives inside its host or succumbs to programmed cell death, according to a new study published in Acta Parasitologica. Researchers led by Yuanzhao Sun and Haoran…...

1+ day, 2+ hour ago   (597+ words) The genomes of true frogs have long puzzled geneticists. Amphibians are famous for carrying some of the largest and most repetitive genomes among vertebrates, and yet the detailed architecture of their repetitive DNA has remained poorly explored compared with mammals,…...

1+ day, 4+ hour ago   (634+ words) For years, immunologists have regarded neutrophils as short-lived first responders, cells that surge into infected or injured tissue, unleash a burst of antimicrobial chemicals, and then die within hours....

1+ day, 5+ hour ago   (746+ words) A sweeping new review published in Discover Chemistry charts the remarkable rise of proteolysis-targeting chimeras, better known as PROTACs, from a bold theoretical idea to one of the most closely watched platforms in modern drug discovery. Written by Sandip G....

1+ day, 6+ hour ago   (87+ words) Cellular senescence, one of the most closely studied hallmarks of aging, has long been a paradox in biology. On the one hand, it protects organisms by halting the division of damaged cells that might otherwise become cancerous. On the other,…...

1+ day, 11+ hour ago   (99+ words) Every day, billions of cells in the human body die in a controlled and deliberate fashion, a process that scientists have come to call regulated cell death. Far from being a simple collapse, many of these deaths culminate in a…...

1+ day, 11+ hour ago   (83+ words) Inside the nucleus of every human cell, roughly two meters of DNA are packed into a space only a few micrometers across, and how that packing is organized has profound consequences for health and disease. A new study published in…...