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News
Protein Assembly, Not Abundance, Explains Why Cells Behave So Differently
3+ hour, 1+ min ago (689+ words) For decades, biologists have treated protein abundance as the closest available proxy for what a cell is actually doing. Measure how much of each protein a cell produces, the reasoning went, and you have a reasonable snapshot of its functional…...
Transfer Learning Reconstructs the Signaling Histories of Single Cells
4+ hour, 33+ min ago (704+ words) Every cell in the body carries a hidden biography. Long before a researcher harvests a tissue and sequences its contents, that cell has been bombarded by hormones, growth factors, cytokines and stress signals, and its current state is the accumulated…...
Cryo-EM Reveals the Dynamic Machinery That Switches Genes On
6+ hour, 45+ min ago (83+ words) Every cell in the human body carries the same genome, yet a neuron, a hepatocyte, and an immune cell behave in utterly different ways. The difference lies in which genes are switched on, when, and where. That act of switching,…...
NINJ1: The Membrane-Rupturing Protein That Decides How Cells Die and How
7+ hour, 2+ min ago (99+ words) Every day, billions of cells in the human body die in a controlled and deliberate fashion, a process that scientists have come to call regulated cell death. Far from being a simple collapse, many of these deaths culminate in a…...
Biobots arise from the cells of dead organisms − pushing the boundaries of life, death and medicine
7+ hour, 36+ min ago (334+ words) Given the right conditions, certain types of cells are able to self-assemble into new lifeforms after the organism they were once part of has died....
Newly Identified GPCR-Like Protein TM184C Controls Cellular Exchange and
8+ hour, 23+ min ago (850+ words) A protein called TM184C has emerged as an unexpected player in two of the most fundamental processes in cellular life: the movement of materials between cells and the controlled recycling of a cell’s own internal components....
New Computational Framework Tracks Cell Migration Across Space and Time
17+ hour, 15+ min ago (879+ words) Scientists have unveiled a new computational framework that brings together two of the most powerful technologies in modern biology—single-cell RNA sequencing and spatial transcriptomics—to reconstruct how populations of cells redistribute and change state across time within living tissues....
Why Laboratory Cell Models Matter in Modern Medical Research
23+ hour, 4+ min ago (350+ words) Many diseases begin with changes that occur at the level of individual cells. Genetic mutations, altered signaling pathways, and abnormal responses to environmental factors can all contribute to disease development. Developing a new medicine involves extensive testing before a potential…...
Genetic Suppressors Rescue Tubulin Mutations and Restore Microtubule
17+ hour, 42+ min ago (757+ words) Microtubules are among the most essential structures in any cell, hollow filaments built from α- and β-tubulin dimers that provide mechanical scaffolding, act as railways for intracellular transport, and form the spindle apparatus that segregates chromosomes during division. When the…...
Chromatin Regulator ANKRD11 Emerges as Switch That Reinvigorates Exhausted
17+ hour, 50+ min ago (736+ words) Chronic hepatitis B virus infection remains one of the most stubborn immunological challenges in medicine, largely because the CD8+ T cells that should destroy infected liver cells gradually lose their killing power....