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Vibrio cholerae acquires antiviral defenses through horizontal gene transfer
2+ hour, 1+ min ago (479+ words) Like most bacteria, Vibrio cholerae lives under constant attack from viruses. To survive, bacteria equip themselves with antiviral immune systems. Previous work showed that V. cholerae carries a large genetic element called a sedentary chromosomal integron (SCI). This structure contains hundreds…...
Study maps DNA methylation changes driving MDS stem cell dysfunction
2+ hour, 4+ min ago (691+ words) Published on April 01, 2026, in Volume 2, article number 19 of the journal Immunity & Inflammation, a collaborative team led by Prof. Cao at the Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, along with Dr. Liangding Hu at the Fifth Medical…...
Low oxygen triggers regenerative programs in mammalian limb cells
1+ hour, 58+ min ago (673+ words) Some animals can regrow lost body parts. Salamanders and frog tadpoles can rebuild entire limbs after amputation. Mammals cannot. For decades, biologists have tried to understand why. Limb regeneration begins with wound healing. After amputation, cells at the injury site…...
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2+ hour, 9+ min ago (10+ words) One letter DNA change switches sex development in mice'News-Medical...
Novel catalytic approach accelerates synthesis of branched drug compounds
3+ hour, 21+ min ago (888+ words) News-Medical Novel catalytic approach accelerates synthesis of branched drug compounds When chemists design drug candidates, shape matters enormously. Many active pharmaceutical ingredients contain branched carbon structures-points where the molecular chain forks in a specific direction-that are critical to whether a…...
AI-powered chemistry accelerates discovery of selective cancer inhibitors
3+ hour, 10+ min ago (1015+ words) Recently, the Insilico team's research entitled "An Internal Sulfur-Lone Pair Interaction Enabled the Discovery of Potential and Sub-Family Selective PKMYT1 Inhibitors" was invited for publication as a cover Feature in Chem Med Chem. AI-powered chemistry accelerates discovery of selective cancer inhibitors…...
Korean skincare ingredient emerges as potential antibiotic candidate
3+ hour, 14+ min ago (167+ words) Fans of Korean skincare may be familiar with 'hero ingredient' Madecassic acid for its skin-soothing properties, but researchers at the University of Kent have revealed its greater potential for use in the battle against antibiotic resistance. Using a combination of…...
Dynamic binding of linker histone H1 shapes flexible chromatin organization
3+ hour, 17+ min ago (254+ words) DNA inside the nucleus is not packed as a rigid regular fiber-linker histone H1 dynamically binds and loosely "glues" nucleosomes together, creating a dynamic, fluid organization that can still support essential genome functions. The team published their results in Science Advances…...
UVA scientists develop AI tools to accelerate new drug discovery
14+ hour, 16+ min ago (228+ words) University of Virginia School of Medicine scientists have developed a bold new approach to drug development and discovery that could dramatically accelerate the creation of new medicines. A companion tool, Yuel Pocket, identifies exactly where on a protein a drug…...
Fat-producing enzyme identified as key driver of damage in Parkinson's disease
16+ hour, 38+ min ago (680+ words) News-Medical Fat-producing enzyme identified as key driver of damage in Parkinson's disease A fat-producing enzyme in brain cells may play a key role in driving damage in Parkinson's disease and could offer a new target for treatment, scientists at Nanyang…...