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Small intracellular vesicles outperform small extracellular vesicles in uptake, drug delivery and retinal neuroprotection - Nature Biomedical Engineering
17+ min ago (1697+ words) In conclusion, sIVs represent a distinct class of intracellular nanovesicles with a molecular profile rich in organelle-associated proteins and miRNAs, a simple and efficient separation method and a high yield. Their small size and cell-inherent properties enable efficient tissue uptake,…...
GCN5–ERK lactylation–phosphorylation loop amplifies lactate-driven cancer progression - Nature Chemical Biology
2+ hour, 4+ min ago (1741+ words) Nature Chemical Biology (2026)Cite this article RNA-seq data were deposited to the Genome Sequence Archive of the China National Center for Bioinformation under BioProject PRJCA048893. All other data supporting the findings of this study are available within the paper and its…...
Plate lattices: advanced architectures for multifunctionality - npj Metamaterials
3+ hour, 10+ min ago (1207+ words) No datasets were generated or analysed during the current study. Du Plessis, A. et al. Properties and applications of additively manufactured metallic cellular materials: a review. Prog. Mater. Sci. 125, 100918 (2022). Ma, W. W. S. et al. Multi-Physical Lattice Metamaterials Enabled by Additive Manufacturing: Design Principles,…...
Wnt3a promotes in situ dentin formation through NKD1-MSX1 axis-mediated odontogenic differentiation of dental pulp stem cells - International Journal of Oral Science
4+ hour, 9+ min ago (1600+ words) Schematic diagram illustrating the mechanism by which Wnt3a induces odontogenic differentiation of dental pulp stem cells via NKD1-MSX1 axis to promote in situ dentin formation Human DPSCs were purchased from Procell Co. Cells were maintained in "-MEM (Gibco) supplemented with 10% FBS (Gibco),…...
Maternal copy number variations detected by noninvasive prenatal testing in Japanese women - Journal of Human Genetics
4+ hour, 48+ min ago (792+ words) Journal of Human Genetics (2026)Cite this article Sasaki Y, Yamada T, Tanaka S, Sekizawa A, Hirose T, Suzumori N, et al. Evaluation of the clinical performance of noninvasive prenatal testing at a Japanese laboratory. J Obstet Gynaecol Res. 2021;47:343746. Jensen TJ,…...
Disposable Point of Care multiplexed plasmonic biosensor for rapid and specific identification of respiratory viruses - npj Biosensing
6+ hour, 14+ min ago (1512+ words) As an alternative to molecular tests, rapid antigen tests (RATs) based on lateral-flow assays can be used at the point-of-care by non-specialized personnel and the end-user. These tests allow for the rapid ( According to these last conditions and the results…...
Fresh starts: how to thrive when you leave academia
12+ hour, 19+ min ago (911+ words) Josie Glausiusz is a freelance science journalist who specializes in the Middle East. A career makeover can allow scientists to explore their passions.Credit: Getty Nick Sheron starts most days by strolling across his six-hectare farm with his two golden…...
AIs are biased toward some Indian castes — how can researchers fix this?
12+ hour, 19+ min ago (490+ words) Popular artificial-intelligence (AI) models often reproduce harmful stereotypes about Indian castes, find several studies that used specific tools designed to detect "caste bias" in large language models (LLMs). Researchers say such tools are the first step towards addressing the problem,…...
Don’t go (phase) changing - Nature Chemical Engineering
13+ hour, 28+ min ago (186+ words) Polymer membranes able to separate organic molecules present in hydrocarbon liquids were demonstrated in the 1960s and first commercialized in the 1990s. Now, a new generation of research advocates using advanced polymer membranes to separate large-scale hydrocarbon mixtures, such as crude oils....
Measurement of the gas consumption history of a massive quiescent galaxy - Nature Astronomy
14+ hour, 25+ min ago (1827+ words) Nature Astronomy (2026)Cite this article Glazebrook, K. et al. A massive, quiescent galaxy at a redshift of 3.717. Nature 544, 7174 (2017). Schreiber, C. et al. Dust temperature and mid-to-total infrared color distributions for star-forming galaxies at 0" Nanayakkara, T. et al. A population of faint, old, and…...